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Sigma-Aldrich

Aminoguanidine bicarbonate

97%

Sinônimo(s):

Aminoguanidine hydrogencarbonate, Guanylhydrazine hydrogencarbonate

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About This Item

Fórmula linear:
NH2NHC(=NH)NH2 · H2CO3
Número CAS:
2582-30-1
Peso molecular:
136.11
Beilstein:
3569869
Número CE:
219-956-7
Número MDL:
MFCD00012949
Código UNSPSC:
12352100
ID de substância PubChem:
24846902
NACRES:
NA.22

Ensaio

97%

pf

170-172 °C (dec.) (lit.)

solubilidade

H2O: soluble 2.7 g/L at 20 °C
H2O: soluble 3.3 g/L at 30 °C

cadeia de caracteres SMILES

OC(O)=O.NNC(N)=N

InChI

1S/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)

chave InChI

OTXHZHQQWQTQMW-UHFFFAOYSA-N

Aplicação

Aminoguanidine bicarbonate was used to study the effect of addition of polyamines to rat embryo cell cultures infected with adenovirus type 5.

Ações bioquímicas/fisiológicas

Aminoguanidine bicarbonate protects the cells infected with adenovirus from chromosomal damage. Aminoguanidine is a specific and highly effective inhibitor of diamine oxidase present in fetal calf serum.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H317,H411

Declarações de precaução

P273 - P280 - P302 + P352

Classificações de perigo

Aquatic Chronic 2 - Skin Sens. 1

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Sigma-Aldrich

A80602

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8-Aminoguanine ≥95% (HPLC)

Sigma-Aldrich

SML1856

8-Aminoguanine

Cinzia Antognelli et al.
Cells, 8(6) (2019-06-09)
Methylglyoxal (MG) is a potent inducer of advanced glycation end products (AGEs). MG, long considered a highly cytotoxic molecule with potential anticancer value, is now being re-evaluated to a protumorigenic agent in some malignancies. Anaplastic thyroid cancer (ATC) is an
A J Bellett et al.
Chromosoma, 84(4), 571-583 (1982-01-01)
Adenovirus uncouples DNA replication from polyamine biosynthesis and causes chromosome aberrations in rodent cells. Addition of polyamines protected infected cells from this chromosome damage. Spermine was the only individual polyamine which protected. The diamine oxidase inhibitor aminoguanidine also protected. Neither
Catiúcia R M O Matos et al.
Dalton transactions (Cambridge, England : 2003), 49(45), 16359-16367 (2020-05-28)
The Cu(ii) heptanuclear complex (Cu7atac) was synthesised using the hydrated amino acid ligand 2-(5-amino-1H-1,2,4-triazol-3-yl)acetic acid (Hatac·H2O). Single crystal X-ray diffraction analysis revealed a μ3-hydroxo bridged Cu(ii) heptanuclear complex, consisting of two triangular subunits and one Cu(ii) ion as a bridge
Sebastiano Intagliata et al.
Antioxidants (Basel, Switzerland), 10(1) (2020-12-31)
Resveratrol (RSV) is well known for its many beneficial activities, but its unfavorable physicochemical properties impair its effectiveness after systemic and topical administration; thus, several strategies have been investigated to improve RSV efficacy. With this aim, in this work, we
Paola Mirra et al.
Biochimica et biophysica acta, 1863(2), 440-449 (2016-11-20)
Methylglyoxal (MGO) is a reactive dicarbonyl produced as by-product of glycolysis, and its formation is heightened in hyperglycaemia. MGO plasma levels are two-fold to five-fold increased in diabetics and its accumulation promotes the progression of vascular complications. Impairment of endothelium-derived
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