ELANE
elastase, neutrophil expressed
Sinônimos:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Espécies:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), domestic guinea pig Elane (100724414), cow ELANE (100126050), Horse ELANE (100462967), domestic cat ELANE (100301482), dog ELANE (442980)
ID UniProtKB:
ID do gene:
- Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
- Mouse(50701) elastase, neutrophil expressed
- Rat(299606) elastase, neutrophil expressed
- sheep(101110841) elastase, neutrophil expressed
- domestic guinea pig(100724414) elastase, neutrophil expressed
- cow(100126050) elastase, neutrophil expressed
- Horse(100462967) elastase, neutrophil expressed
- domestic cat(100301482) elastase, neutrophil expressed
- dog(442980) elastase, neutrophil expressed
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Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Neutrophil Elastase Antibody, clone AHN-10, clone AHN-10, from mouse,
Reatividade de espécies
human
Aplicação
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
Anti-Neutrophil Elastase Rabbit pAb, liquid, Calbiochem®,
Reatividade de espécies
human
Aplicação
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
Reatividade de espécies
mouse
Aplicação
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Neutrophil Elastase Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human
Aplicação
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Proteins
esiRNA
Número do produto
Descrição
Espécies