CHRNA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
Sinônimos:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Espécies:
Human CHRNA4 (1137), Mouse Chrna4 (11438), Rat Chrna4 (25590), sheep CHRNA4 (101118889), Domestic Rabbit CHRNA4 (100345481), domestic guinea pig Chrna4 (100716877), naked mole-rat Chrna4 (101714448), Zebrafish chrna4 (556619), domestic cat CHRNA4 (101101300), cow CHRNA4 (537251) ...Mais
ID UniProtKB:
ID do gene:
- Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
- Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
- Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
- domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- cow(537251) cholinergic receptor, nicotinic, alpha 4
- Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- chicken(395606) cholinergic receptor, nicotinic, alpha 4
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Agonist
Número do produto
Descrição
Espécies
S(−)-Nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espécies
human
(−)-Nicotine hemisulfate salt, ≥95% (TLC), ~35 % (w/v) in H2O (based on free base),
Espécies
human
Small Molecule - Antagonist
Número do produto
Descrição
Espécies
Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-nAChR α4 Subunit Antibody, clone 369, clone 369, from mouse,
Reatividade de espécies
human, monkey, rabbit
Aplicação
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Nicotinic Acetylcholine Receptor α4 Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
human, mouse, rat
Aplicação
western blot
Anti-ACHA4 antibody produced in rabbit, ,
Reatividade de espécies
human, mouse, rat
Aplicação
immunohistochemistry
western blot
western blot
Anti-CHRNA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
western blot