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P3076

Sigma-Aldrich

Platelet-Derived Growth Factor-AA human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

PDGF−AA

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About This Item

Numéro MDL:
MFCD00081862
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Platelet-Derived Growth Factor-AA human, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Puissance

1.0-3.0 ng/mL ED50

Qualité

endotoxin tested

Poids mol.

28.5 kDa (containing 250 amino acid residues)

Conditionnement

pkg of 10 μg
pkg of 50 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

cell culture | mammalian: suitable

Impuretés

<1 EU/μg

Numéro d'accès UniProt

P04085

Température de stockage

−20°C

Informations sur le gène

human ... PDGFRA(5154)

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Catégories apparentées

Description générale

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Actions biochimiques/physiologiques

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Autres remarques

Homodimer of the A chain of human PDGF.

Forme physique

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Remarque sur l'analyse

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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