SRP6313

Alpha 2 Antiplasmin from human plasma

≥95% (SDS-PAGE), lyophilized

• Synonym(e): AAP, Alpha-2-plasmin inhibitor, PLI, SERPINF2
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• product name: Alpha 2 Antiplasmin from human plasma, ≥95% (SDS-PAGE)
• Biologische Quelle: human
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized
• Wirksamkeit: ≥5.0 I.U. per mg
• Mol-Gew.: 70 kDa
• Verpackung: pkg of 100 μg
• UniProt-Hinterlegungsnummer: P08697
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... SERPINF2(5345)

Beschreibung

Allgemeine Beschreibung

α-2 antiplasmin (AAP) is a member of the Serpin superfamily. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. The gene encoding this protein is localized on human chromosome 17.

α-2 antiplasmin (AAP) is a member of the Serpin superfamily. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. The AAP gene is mapped to human chromosome 17p13 and codes for a glycoprotein of single chain containing 464 amino acid residues.

Biochem./physiol. Wirkung

α-2 antiplasmin (AAP) is the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. α-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.

α-2 antiplasmin (AAP) is the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. It inhibits the action of protease by the formation In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. α-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. AAP is known to inhibit fibrinogenolysis by preventing free plasmin circulation.

Physikalische Form

Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.

Rekonstituierung

In water or aqueous buffer

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3