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A9024

Sigma-Aldrich

α1-Antitrypsin aus Humanplasma

salt-free, lyophilized powder

Synonym(e):

α1-Proteinase-Inhibitor

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About This Item

CAS-Nummer:
9041-92-3
EG-Nummer:
232-924-7
MDL-Nummer:
MFCD00130469
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human plasma

Qualitätsniveau

200

Assay

≥70% protein basis (biuret)

Form

salt-free, lyophilized powder

UniProt-Hinterlegungsnummer

P01009
P08246

Lagertemp.

2-8°C

Angaben zum Gen

human ... ELA2(1991) , SERPINA1(5265)

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Biochem./physiol. Wirkung

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.

Vorsicht

Wässrige Stammlösungen mit 0.01% NaN3 sind mehrere Monate lang stabil Die Lösungen können bei -80°C aufbewahrt werden, sollten aber nach dem Auftauen nicht wieder eingefroren werden. Instabil unterhalb pH 5.5. Wird inaktiviert durch einige non-serine Proteasen und durch Oxidation der Methionin Seitenkette des aktiven Zentrums.

Angaben zur Herstellung

Chromatographically prepared and partially purified.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Roy B Lefkowitz et al.
Analytical chemistry, 82(19), 8251-8258 (2010-09-11)
The ability to measure protease activity in the blood is important for the development of future diagnostics and for biomedical research. Presently, protease assays require sample preparation, making them time-consuming, costly, less accurate, and unsuitable for point-of-care (POC) diagnostics. Recently
B Halliwell et al.
FEBS letters, 213(1), 15-17 (1987-03-09)
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint
M Wasil et al.
The Biochemical journal, 243(3), 867-870 (1987-05-01)
Thiourea and dimethylthiourea are powerful scavengers of hydroxyl radicals (.OH), and dimethylthiourea has been used to test the involvement of .OH in several animal models of human disease. It is shown that both thiourea and dimethylthiourea are scavengers of HOCl
Cynthia L Bristow et al.
Journal of immunology (Baltimore, Md. : 1950), 180(1), 492-499 (2007-12-22)
To identify positive or negative factors for HIV-1 infectivity, clones from the U937 promonocytic cell line that express similar levels of CD4 and CXCR4, but differ in HIV-1 susceptibility, were compared. In contrast to HIV-1 permissive clone 10 (plus), nonpermissive
M Whiteman et al.
FEBS letters, 414(3), 497-500 (1997-10-10)
Peroxynitrite (ONOO-) is a cytotoxic species formed in vivo. There is considerable interest in the development of ONOO- 'scavengers' as therapeutic agents; several thiols have been suggested to fulfil this role. One protein inactivated by ONOO- is alpha1-antiproteinase (alpha1AP), the
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Artikel

Elastase

Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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