SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• Synonym(e): 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• Empirische Formel (Hill-System): C₁₆H₁₉N₃O₃ · 2HCl
• CAS-Nummer: 32434-42-7
• Molekulargewicht: 374.26
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825583
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D 10 to 15°, c = 1 in H₂O
• Lagerbedingungen: desiccated
• Farbe: off-white to gray-brown
• Löslichkeit: H₂O: 15 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChIKey: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Beschreibung

Biochem./physiol. Wirkung

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable