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Wichtige Dokumente
SMB00314
Coptisine Chloride
≥98% (HPLC)
Synonym(e):
Coptisine chloride, Bis(methylenedioxy)protoberberine chloride, Coptisin Chloride
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About This Item
Empirische Formel (Hill-System):
C19H14ClNO4
CAS-Nummer:
Molekulargewicht:
355.77
MDL-Nummer:
UNSPSC-Code:
12352205
PubChem Substanz-ID:
NACRES:
NA.25
Empfohlene Produkte
Qualitätsniveau
Assay
≥98% (HPLC)
Form
powder
Anwendung(en)
metabolomics
vitamins, nutraceuticals, and natural products
Lagertemp.
−20°C
SMILES String
C1(OCO2)=C2C=C(CC[N+]3=C4C=C5C(C(OCO6)=C6C=C5)=C3)C4=C1.[Cl-]
InChI
1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
InChIKey
LUXPUVKJHVUJAV-UHFFFAOYSA-M
Verwandte Kategorien
Allgemeine Beschreibung
Coptisine chloride is a cytotoxic isoquinoline alkaloid. It is the major bioactive compound of Coptis rhizome, and can also be found in different plants such as Chelidonium majus, Enantia chlorantha. Coptisine is related to berberine and has a similar structure to that of Jatrorrhizine.
Anwendung
Coptisine Chloride has been used to study its binding interactions with single-stranded poly(A) using different absorbance and thermal melting spectroscopic experiments. It may have been used as a standard to analyze Chelidonium majus L. extracted compounds using UV/VIS absorption spectroscopy.
Biochem./physiol. Wirkung
Coptisine Chloride is a potent anti-malarial compound, which also exerts anti-cancer and anti-diabetic properties. It elicits protective effects on gastric mucus membrane and is used as a traditional medicine against gastroenteric diseases. Coptisine chloride also displays anti-microbial activities.It has been analyzed as a cytotoxic agent in hepatoma and leukemic cells and is reported to block cell cycle progression.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
Lagerklassenschlüssel
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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All messenger RNAs (mRNAs) have a polyadenylic acid tail that is added during post transcriptional RNA processing. Investigation of the structure-function and interactions of polyadenylic acid is an important area to target for cancer and related diseases. Jatrorrhizine and coptisine
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It has been shown that secondary metabolites occur in Chelidonium majus L. (C. majus) crude extract and milky sap (alkaloids such as berberine, coptisine, chelidonine, chelerythrine, sanguinarine, and protopine) are biologically active compounds with a wide spectrum of pharmacological functions.
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