P6004

Prednisolon

≥99% (HPLC), powder, glucocorticoid

• Synonym(e): 1,4-Pregnadien-11β,17α,21-triol-3,20-dion, 1-Dehydrocortisol, 1-Dehydrohydrocortison, 11β,17α,21-Trihydroxy-1,4-pregnadien-3,20-dion
• Empirische Formel (Hill-System): C₂₁H₂₈O₅
• CAS-Nummer: 50-24-8
• Molekulargewicht: 360.44
• Beilstein: 1354103
• EG-Nummer: 200-021-7
• MDL-Nummer: MFCD00003649
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24898725
• NACRES: NA.77

Eigenschaften

• product name: Prednisolon, ≥99%
• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Sterilität: non-sterile
• Assay: ≥99%
• Form: powder
• mp (Schmelzpunkt): 240 °C (dec.) (lit.)
• Löslichkeit: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• Ersteller: Johnson & Johnson
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• Angaben zum Gen: human ... AR(367) , ESR1(2099) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Nr3c1(14815) ; rat ... Ar(24208)

Beschreibung

Allgemeine Beschreibung

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Anwendung

Prednisolone has been used for the Δ¹-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Biochem./physiol. Wirkung

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Hinweis zur Analyse

Actual content given on label

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360FD
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves