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Key Documents

SAB5200112

Sigma-Aldrich

Anti-Aquaporin-4 Antibody

rabbit polyclonal

Synonym(e):

Anti-AQP4, Anti-Aquaporin 4

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

product name

Anti-AQP4 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous glycerol solution

Mol-Gew.

antigen predicted mol wt 35 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

1 mg/mL

Methode(n)

indirect immunofluorescence: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_036957.1

UniProt-Hinterlegungsnummer

P55087

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

rat ... Aqp4(25293)

Allgemeine Beschreibung

Aquaporin 4 (AQP4) is expressed in the nervous system. The gene ID of the protein is 25293.

Spezifität

Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.

Immunogen

C-terminal peptide

Biochem./physiol. Wirkung

Aquaporin 4 (AQP4) functions as a water channel in the rat brain.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

PBS, pH 7..4, 50% glycerol, and 0.09% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

S Ceccariglia et al.
Neuroscience, 274, 273-288 (2014-06-10)
Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evidenced dilation of lateral ventricles, also suggesting alterations in blood-brain
Alex J Smith et al.
Acta neuropathologica communications, 7(1), 74-74 (2019-05-10)
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to
Gökhan Akdemir et al.
Neuroscience letters, 574, 70-75 (2014-04-11)
Astrocyte water channel aquaporin-4 (AQP4) facilitates water movement across the blood-brain barrier and into injured astrocytes. We previously showed reduced cytotoxic brain edema with improved neurological outcome in AQP4 knockout mice in water intoxication, infection and cerebral ischemia. Here, we
Jungo Kato et al.
Biochemical and biophysical research communications, 451(4), 562-567 (2014-08-16)
Aquaporin-4 (AQP4) is a water channel protein that is predominantly expressed in astrocytes in the CNS. The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS. On the other hand, little

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