SAB4300434

Anti-PAK1/PAK2/PAK3 (Ab-423/402/421) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-CDKN1A antibody produced in rabbit, Anti-MGC130000 antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit, Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 / 2 / 3 antibody produced in rabbit
• MDL-Nummer: MFCD02097133
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 61-67 kDa; 68-74 kDa
• Speziesreaktivität: rat, human, mouse
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• Isotyp: IgG
• Immunogene Sequenz: (R-S-T-M-V)
• NCBI-Hinterlegungsnummer: NP_001121638.1; NP_001122092.1; NP_002568.2
• UniProt-Hinterlegungsnummer: Q13177
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

Beschreibung

Immunogen

Peptide sequence around aa. 421-425/400-404/419-423 (R-S-T-M-V), according to the proteins PAK1/PAK2/PAK3.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable