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RAB1122

Sigma-Aldrich

Mouse EPO ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

UNSPSC-Code:
41116158
NACRES:
NA.32

Speziesreaktivität

mouse

Verpackung

kit of 96 wells (12 strips x 8 wells)

Methode(n)

ELISA: suitable

Aufnahme

sample type cell culture supernatant(s)
sample type plasma
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.5 pg/ml

Nachweisverfahren

colorimetric

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

mouse ... Epo(13856)

Allgemeine Beschreibung

This ELISA antibody pair detects Mouse Erythropoietin (EPO)

Anwendung

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem./physiol. Wirkung

Erythropoietin (EPO) is a glycoprotein hormone which is essential for the proliferation of erythropoietic progenitors to produce red blood cells (RBCs). Peritubular fibroblast in kidney cortex is the primary site for EPO production in adults, though spleen, bone marrow and liver contribute to the production. In fetus, liver is the primary site for EPO production. Additionally, EPO functions in some cytoprotective activities like, antiapoptotic, antioxidant, and anti-inflammatory responses. Hypoxia inducible factors upregulate EPO expression. EPO expression increases with decreased hemoglobin concentration in few cases of anemia. Decreased production of EPO is the cause of anemia in chronic kidney diseases. Circulating endogenous antibodies to EPO (anti-EPO) is the cause of anemia in multiple diseases like human immunodeficiency virus (HIV) infection, hepatitis C virus infection, systemic lupus erythematosus. Gain-of-function polymorphism in EPO causes familial erythrocytosis.

Sonstige Hinweise

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Piktogramme

Corrosion
GHS05

Signalwort

Warning

H-Sätze

H290

P-Sätze

P234 - P390

Gefahreneinstufungen

Met. Corr. 1

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
Tsiakalos A, et al.
Hepatobiliary & Pancreatic Diseases International : HBPD INT, 16(3), 289-295 (2017)
Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells
Nishimura K, et al.
Archives of Biochemistry and Biophysics, 636, 11-16 (2017)
Physiology and pharmacology of erythropoietin
Jelkmann W
Transfusion Medicine and Hemotherapy : Offizielles Organ der Deutschen Gesellschaft Fur? Transfusionsmedizin und Immunham?atologie, 40(5), 302-309 (2013)
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis
Zmajkovic J, et al.
The New England Journal of Medicine, 378(10), 924-930 (2018)

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