P1645

O-Palmitoyl-L-carnitin -hydrochlorid

≥98% (TLC), powder

• Synonym(e): Palmitoyl-L-Carnitinchlorid
• Lineare Formel: C₂₃H₄₆NO₄ · Cl
• CAS-Nummer: 18877-64-0
• Molekulargewicht: 436.07
• Beilstein: 4071005
• EG-Nummer: 242-642-6
• MDL-Nummer: MFCD00070346
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 24898229
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Farbe: white
• Löslichkeit: H₂O: 25 mg/mL (with heat or sonication)
• Lipid-Typ: saturated FAs
• Lagertemp.: −20°C
• SMILES String: [Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
• InChI: 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
• InChIKey: GAMKNLFIHBMGQT-ZMBIFBSDSA-N

Beschreibung

Anwendung

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).

Biochem./physiol. Wirkung

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves