M5191

Anti-Matrix Metalloproteinase-28, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(e): Anti-Epilysin, Anti-MMP-28
• MDL-Nummer: MFCD04040453
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Speziesreaktivität: human
• Konzentration: ~1 mg/mL
• Methode(n): western blot: 1:1,000
• UniProt-Hinterlegungsnummer: Q9H239
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... MMP28(79148)

Beschreibung

Allgemeine Beschreibung

Matrix metalloproteinase-28 (MMP-28) is expressed in normal tissues like the epidermis of the skin, brain, lungs and intestine. It possesses an activation sequence and a pro-domain. The gene encoding it is localized on human chromosome 17q11.2 and has eight exons.

Spezifität

By immunoblotting against the reduced protein, the antibody identifies bands at 62 kDa and 58 kDa, as well as breakdown products at 50 kDa, 48 kDa, and 46 kDa. At higher antibody concentrations, the antibody also detects a 70 kDa band in rat and mouse tissues.

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-28.

Biochem./physiol. Wirkung

Matrix metalloproteinase-28 (MMP-28) may have a role in modulating matrix composition. It is an endopeptidase which degrades casein and mediates epithelial to mesenchymal transition. MMP-28 aids in progression of tumors and is overexpressed in gastric carcinomas.

Physikalische Form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)