M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Synonym(e): 6-(1-Piperidinyl)-2,4-pyrimidindiamin-3-oxid, 6-(1-Piperidinyl)-pyrimidin-2,4-diamin-3-oxid
• Empirische Formel (Hill-System): C₉H₁₅N₅O
• CAS-Nummer: 38304-91-5
• Molekulargewicht: 209.25
• EG-Nummer: 253-874-2
• MDL-Nummer: MFCD00063409
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277853
• NACRES: NA.77

Eigenschaften

• product name: Minoxidil, ≥99% (TLC)
• Assay: ≥99% (TLC)
• mp (Schmelzpunkt): 272-274 °C (dec.) (lit.)
• Ersteller: Johnson & Johnson
• SMILES String: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• InChIKey: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Angaben zum Gen: human ... KCNJ1(3758)

Beschreibung

Anwendung

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Biochem./physiol. Wirkung

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Aktiviert ATP-aktivierte K⁺-Kanäle; Vasodilatator; verlangsamt oder stoppt Haarausfall und fördert das Nachwachsen von Haaren.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves