A9968

N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide

≥95%

• Synonym(e): Ac-IETD-pNA
• Empirische Formel (Hill-System): C₂₇H₃₈N₆O₁₂
• Molekulargewicht: 638.62
• MDL-Nummer: MFCD01318840
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 329771065
• NACRES: NA.32

Eigenschaften

• Assay: ≥95%
• Form: powder
• Lagertemp.: −20°C
• SMILES String: CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
• InChI: 1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
• InChIKey: FHURKTIGZAIQGR-BQCLNCLCSA-N
• Angaben zum Gen: human ... CARD8(22900) , CASP8(841) , CASP8AP2(9994) , CFLAR(8837) , GZMB(3002) ; mouse ... CFLAR(117279) , GZMB(171528) ; rat ... CASP8(12370) , CFLAR(12633) , GZMB(14939) , RGD1561819(502004) , RGD1562700(502007)

Beschreibung

Amino Acid Sequence

NAc-Ile-Glu-Thr-Asp-pNA

Anwendung

Chromogenic substrate for caspase 8 and granzyme B.

Biochem./physiol. Wirkung

IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)