PHR1782

Hydroxychloroquinsulfat -sulfat

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 7-Chlor-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]chinolinsulfat
• Empirische Formel (Hill-System): C₁₈H₂₆ClN₃O · H₂SO₄
• CAS-Nummer: 747-36-4
• Molekulargewicht: 433.95
• EG-Nummer: 212-019-3
• MDL-Nummer: MFCD00078203
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823611
• NACRES: NA.24

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 300
• Qualität: certified reference material; pharmaceutical secondary standard
• Agentur: BP; EP; USP; traceable to BP 1100; traceable to USP 1327000
• API-Familie: hydroxychloroquine
• Form: powder or crystals
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: pkg of 1 g
• Lagerbedingungen: protect from light
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Farbe: white to off-white
• pH-Wert: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• mp (Schmelzpunkt): 238-241 °C
• Löslichkeit: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• Anwendung(en): pharmaceutical (small molecule)
• Versandbedingung: ambient
• Lagertemp.: 2-30°C
• SMILES String: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• InChIKey: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Angaben zum Gen: human ... TLR7(51284) , TLR9(54106)

Beschreibung

Allgemeine Beschreibung

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Hydroxychloroquinsulfat ist ein entzündungshemmendes (über TNF), krankheitsmodifizierendes Antirheumatikum (DMARD) und ein Hemmstoff der Hämpolymerase. Es wird bei der Behandlung von Malaria eingesetzt.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0287 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319
• P-Sätze: P301 + P312 + P330 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable