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Merck

PHR1717

Supelco

Methylprednisolon

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

6α-Methylprednisolon, 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadien-3,20-dion, 6α-Methyl-11β,17a,21-trihydroxy-1,4-pregnadien-3,20-dion, Medrol, Medron

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About This Item

Empirische Formel (Hill-System):
C22H30O5
CAS-Nummer:
Molekulargewicht:
374.47
Beilstein:
2340300
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to BP 248
traceable to Ph. Eur. M1750000
traceable to USP 1435003

API-Familie

methylprednisolone

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 500 mg

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

InChIKey

VHRSUDSXCMQTMA-PJHHCJLFSA-N

Angaben zum Gen

human ... NR3C1(2908)

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Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methylprednisolone is a synthetic corticosteroid drug which is employed for the management of inflammatory diseases. It is used to relieve the inflammations caused by psoriasis, eczema, arthritis, asthma and rhinitis. It is also widely employed for the treatment of acute lung injury caused by acid aspiration.

Anwendung

Methylprednisolone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and counterfeit cosmetic products by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB8710 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Repr. 1B - STOT RE 2

Zielorgane

Adrenal gland,Immune system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

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Kunden haben sich ebenfalls angesehen

Methylprednisolone
USP42-NF37
United States Pharmacopeia/National Formulary, 44(3), 2859-2859 (2013)
LC-MS method for the simultaneous determination of six glucocorticoids in pharmaceutical formulations and counterfeit cosmetic products
Fiori J and Andrisano V
Journal of Pharmaceutical and Biomedical Analysis, 91, 185-192 (2014)
Differential pulse voltammetric determination of methylprednisolone in pharmaceuticals and human biological fluids
Goyal RN, et al.
Analytica Chimica Acta, 605(1), 34-40 (2007)
Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode
Goyal RN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1147-1153 (2007)
Simultaneous determination of cortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, mycophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tandem mass spectrometry
DiFrancesco R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 859(1), 42-51 (2007)

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