ABS94

Anti-MLK1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• Methode(n): immunohistochemistry: suitable (paraffin)
• NCBI-Hinterlegungsnummer: NP_149132
• UniProt-Hinterlegungsnummer: P80192
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MAP3K9(4293)

Beschreibung

Allgemeine Beschreibung

MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.

Immunogen

KLH-conjugated linear peptide corresponding to human MLK1.

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Kinasen & Phosphatasen

Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).

Qualität

Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.

Zielbeschreibung

121 kDa (isoform 1), 123 kDa (isoform 2) calculated

Physikalische Form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Colorectal adenocarcinoma tissue

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids