700184M

desmosterol (D6) ester

26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution

• Synonym(e): 111014
• Empirische Formel (Hill-System): C₄₅H₇₀D₆O₂
• CAS-Nummer: 2260669-31-4
• Molekulargewicht: 655.12
• UNSPSC-Code: 12352211
• NACRES: NA.12

Eigenschaften

• Assay: >99% (TLC)
• Form: methylene chloride solution
• Verpackung: pkg of 1 × 1 mL (700184M-1mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 700184M
• Konzentration: 1 mg/mL (700184M-1mg)
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.

Biochem./physiol. Wirkung

Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.

Verpackung

5 mL Clear Glass Sealed Ampule (700184M-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H336,H351
• P-Sätze: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Central nervous system
• WGK: WGK 2