700040P

desmosterol-d6

Avanti Research^™ - A Croda Brand

• Synonym(e): 24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)
• Empirische Formel (Hill-System): C₂₇H₃₈OD₆
• CAS-Nummer: 1246298-67-8
• Molekulargewicht: 390.67
• UNSPSC-Code: 12352100
• NACRES: NA.25

Eigenschaften

• Beschreibung: cholesta-5,24-dien-3β-ol-d6
• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 1 mg (700040P-1mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

Anwendung

Desmosterol-d6 has been used:

• as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
• as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
• for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

Biochem./physiol. Wirkung

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

Verpackung

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids