D99234

Diethylphosphit

98%

• Synonym(e): Diethoxyphosphine oxide, Diethyl acid phosphite, Diethyl hydrogen phosphite, Diethyl phosphonate, Hydrogen diethyl phosphite
• Lineare Formel: (C₂H₅O)₂P(O)H
• CAS-Nummer: 762-04-9
• Molekulargewicht: 138.10
• Beilstein: 605759
• EG-Nummer: 212-091-6
• MDL-Nummer: MFCD00044573
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24894335
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 98%
• Form: liquid
• Brechungsindex: n20/D 1.407 (lit.)
• bp: 50-51 °C/2 mmHg (lit.)
• Dichte: 1.072 g/mL at 25 °C (lit.)
• SMILES String: [H]P(=O)(OCC)OCC
• InChI: 1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3
• InChIKey: MJUJXFBTEFXVKU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Diethyl phosphite is the organophosphorus compound used as a phosphorylating agent in organic synthesis.

Anwendung

Applications of diethyl phosphite (DEP):

• It can undergo condensation with aldehydes or ketones and an amine to form α-aminophosphonates under solvent-free and catalyst-free conditions.
• Reduction of gem-dibromo derivatives using diethyl phosphite in the presence of triethylamine gives monobromocyclopropanes.
• Along with 4-dimethylaminopyridine, it can be used as a ligand for nickel-catalyzed cross-coupling of aryl and heteroaryl bromides, chlorides or sulfonates with arylzinc reagents.
• It can be used for the catalytic asymmetric hydrophosphonylation of enones in the presence of a dinuclear zinc complex to form γ-oxo-phosphonates.
• DEP can undergo Michael addition to α,β-unsaturated malonates to form β-phosphonomalonates in the presence of recyclable nano γ-ferric oxide-pyridine based catalyst.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H317,H318
• P-Sätze: P261 - P272 - P280 - P302 + P352 - P305 + P351 + P338 - P333 + P313
• Gefahreneinstufungen: Eye Dam. 1 - Skin Sens. 1B
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): 179.6 °F - closed cup
• Flammpunkt (°C): 82 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type ABEK (EN14387) respirator filter