902535

Amino-PEG4-t-butyl ester

• Synonym(e): tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H₂N-PEG₄-CH₂CH₂COOtBu, H₂N-dPEG(4)-CO-OtBu
• Empirische Formel (Hill-System): C₁₅H₃₁NO₆
• CAS-Nummer: 581065-95-4
• Molekulargewicht: 321.41
• MDL-Nummer: MFCD11041116
• UNSPSC-Code: 51171641
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reagent type: cross-linking reagent
• Brechungsindex: n/D 1.4508
• Dichte: 1.04479 g/mL
• Funktionelle Gruppe: amine; ester
• Lagertemp.: −20°C
• SMILES String: NCCOCCOCCOCCOCCC(OC(C)(C)C)=O
• InChI: 1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
• InChIKey: PKESARRNSGIDRD-UHFFFAOYSA-N

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable