900814

SLAP TM

≥95%

• Synonym(e): 2-(((Trimethylsilyl)methyl)thio)ethanamine
• Empirische Formel (Hill-System): C₆H₁₇NSSi
• CAS-Nummer: 1226877-72-0
• Molekulargewicht: 163.36
• UNSPSC-Code: 12352200
• NACRES: NA.22

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Brechungsindex: n/D 1.4811
• Dichte: 0.90746 g/mL
• Lagertemp.: 2-8°C
• SMILES String: NCCSC[Si](C)(C)C

Beschreibung

Anwendung

When used with aliphatic or aromatic aldehydes, this silicon amine protocol (SLAP) reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)₂dtbbpy]PF₆ ((747769) is used with a recommended starting combination of Lewis acids Bi(OTf)₃ (633305) and Cu(OTf)₂ (283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents and is well-suited for scale-up reactions.

Sonstige Hinweise

• Technology Spotlight: SLAP Reagents for Piperazine Synthesis
• Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
• Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.
• Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 174.0 °F
• Flammpunkt (°C): 78.89 °C