411361

Diethyl(bromdifluormethyl)phosphonat

96%

• Synonym(e): (Bromodifluoromethyl)phosphonic acid diethyl ester
• Lineare Formel: BrCF₂P(O)(OC₂H₅)₂
• CAS-Nummer: 65094-22-6
• Molekulargewicht: 267.01
• MDL-Nummer: MFCD00069118
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 24865745
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 96%
• Form: liquid
• Eignung der Reaktion: reaction type: C-C Bond Formation
• Brechungsindex: n20/D 1.417 (lit.)
• bp: 40-41 °C/0.05 mmHg (lit.)
• Dichte: 1.503 g/mL at 25 °C (lit.)
• SMILES String: CCOP(=O)(OCC)C(F)(F)Br
• InChI: 1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3
• InChIKey: QRADKVYIJIAENZ-UHFFFAOYSA-N

Beschreibung

Anwendung

Reactant for:

• Preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3)
• Synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps
• P-C bond cleavage on basic hydrolysis
• Preparation of a prodrug for intracellular delivery of protein tyrosine phosphatase 1B (PTP1B) inhibitor (nonhydrolyzable difluoromethylphosphonate moiety)

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves