196789
2,3,5,6-Tetrafluorphenol
97%
Synonym(e):
1,2,4,5-Tetrafluoro-3-hydroxybenzene
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Alle Fotos(1)
About This Item
Empfohlene Produkte
Qualitätsniveau
Assay
97%
Form
solid
bp
140 °C (lit.)
mp (Schmelzpunkt)
37-39 °C (lit.)
Funktionelle Gruppe
fluoro
SMILES String
Oc1c(F)c(F)cc(F)c1F
InChI
1S/C6H2F4O/c7-2-1-3(8)5(10)6(11)4(2)9/h1,11H
InChIKey
PBYIIRLNRCVTMQ-UHFFFAOYSA-N
Anwendung
2,3,5,6-Tetrafluorophenol was used in preparation of :
- radioiodinated phenylalanine derivative which is useful in peptide synthesis
- technetium-99m labeled antibodies
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
174.2 °F - closed cup
Flammpunkt (°C)
79 °C - closed cup
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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The Journal of biological chemistry, 260(10), 5998-6005 (1985-05-25)
The oxidative half-reaction of phenol hydroxylase has been studied by stopped-flow spectrophotometry. Three flavin-oxygen intermediates can be detected when the substrate is thiophenol, or m-NH2, m-OH, m-CH3, m-Cl, or p-OH phenol. Intermediate I, the flavin C(4a)-hydroperoxide, has an absorbance maximum
Proceedings of the National Academy of Sciences of the United States of America, 85(11), 4025-4029 (1988-06-01)
Technetium-99m labeling of antibodies has been suboptimal because of low affinity adventitious binding, nonspecific labeling, and loss of immunoreactivity. The diamide dithiolate ligand system (N2S2) forms highly stable, well-defined tetradentate complexes with Tc(V). Antibodies and their fragments have been labeled
Bioorganic & medicinal chemistry, 27(10), 1925-1931 (2019-04-18)
Folate receptors (FR) are frequently overexpressed in a wide variety of human cancers. The aim of this study was to develop a trivalent 99mTc(CO)3-labeled folate radiotracer containing isonitrile (CN-R) as the coordinating ligand for FR target imaging. [99mTc]Tc-10 was HPLC
Bioconjugate chemistry, 4(6), 574-580 (1993-11-01)
An investigation to prepare a phenylalanine derivative which could be radioiodinated and used directly in peptide synthesis was conducted. N-Boc-p-(tri-n-butylstannyl)-L-phenylalanine tetrafluorophenyl ester was targeted and synthesized from N-Boc-p-iodo-L-phenylalanine. The requisite aryl stannylation reaction was found to be best conducted using
Chemical research in toxicology, 6(5), 674-680 (1993-09-01)
In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the metabolite patterns. In order to study the primary oxidation products
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