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Clarification Depth Filters & Pretreatment Solutions

Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices. 

Millistak+® HC Pro Filters

Millistak+® HC Pro Filters

MILLISTAK+® HC PRO FILTERS

These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications. 

Millistak+® Depth Filters

Millistak+® Depth Filters

Millistak+® Depth Filters

These filters are offered in both Pod and lenticular formats. 

  • Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
  • Millistak+® Carbon  offers enhanced impurity clearance for turbidity reduction and polishing.
  • Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder.
  • Millistak+® CE filters are single layer clarification filters containing cellulose.
Clarisolve® depth filters and polymers

Clarisolve® Depth Filters and Flocculation Polymers

Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated  cell culture harvests.

  • pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.

Support for Qualification, Risk Assessment, and Process Optimization

Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

Find the right filter for your application.

Related Product Resources

mAb Expression, Purification, and Formulation

mAbsizer™ Calculator

Product Selection

Guide: Clarification Portfolio Guide
Flyer: Millistak+® Family and Clarisolve® Depth Filters at a Glance 
Flyer: Clarification of Mammalian Cell Cultures by Depth Filtration

Product Specifications

Data Sheet: Millistak+® HC Pro Synthetic Depth Filters
Data Sheet: Millistak+® Pod Carbon Depth Filter Media System 
Data Sheet: Clarification Solutions for Pre-treated Feed Streams
Data Sheet: Millistak+® Pod Disposable Depth Filter System

Product Operations

Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing 
Article: Complete Clarification Solution for Processing High Density Cell Culture 
Article: Selection of Clarification Methods for Improved Downstream Performance and Economics 
Article: Evolving Clarification Strategies to Meet New Challenges 
Article: Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes 
Article: Development of a Novel and Efficient Cell Culture Flocculation Process Using a Stimulus Responsive Polymer to Streamline Antibody Purification Processes 
Guide: Millistak+® Pod Disposable Depth Filter Performance
Application Note: Millistak+® Activated Carbon for mAb Downstream Purification 
Application Note: pDADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
User Guide: Pod Depth Filters
User Guide: μPod® Filters

Related Product Categories
Clarification Prefilters
Elevate pharma process purity with efficient clarification prefilters. Safeguard downstream operations from impurities.
Clarification Filter Holders and Systems for Bioprocessing
Our flexible hardware and systems for disposable depth filters are ideal for clarification at pilot and process scales, featuring the modular Pod device that enables scale-up and scale-down within the same footprint.
Related Applications
Monoclonal Antibody Manufacturing
Monoclonal antibody manufacturing is a highly templated approach used to produce mAb-based immunotherapies. Robust, scalable process solutions are required at every step to ensure high therapeutic concentration and process safety, while meeting speed-to-market and cost containment concerns.
Gene Therapy Manufacturing
Growing use of gene therapies is driving rapid innovation in an evolving global market. Manufacturers bringing new gene therapies to life face complex challenges, requiring an experienced partner capable of integrating vector manufacturing, testing, safety, process development, and regulatory compliance.
Cell Therapy Manufacturing
Introducing a new cell therapy demands optimal performance in upstream and downstream processing, process development, testing, and manufacturing. World-class products and partners are critical to success, speeding advancement of therapeutics that are effective, safe, and affordable.
Antibody-Drug Conjugate (ADC) Manufacturing
Antibody-drug conjugation (ADC) technology uses monoclonal antibodies (mAbs) to deliver potent, highly active pharmaceutical ingredients (HPAPIs) to targeted cells. Learn about processes and areas of expertise required to advance your ADC to market.
Vaccine Manufacturing
From early phase development, through downstream purification to large scale vaccine production: learn more about vaccine process development and application expertise.
Classical Pharmaceutical Formulation & Manufacturing
Manufacturing the final dosage form of a small molecule drug requires robust quality and design in development of the formulation and production of the final product. Explore solutions and best practices to advance and accelerate small molecule pharmaceuticals, from development to commercialization.
Related Services
Training & Education
Pharmaceutical and biopharmaceutical manufacturers can enhance their skill sets with practical, hands-on training courses in-person or streamed live from our M Lab™ Collaboration Centers.
M Lab™ Collaboration Centers
M Lab™ Collaboration Centers offer in-person or virtual visits with experts to solve the challenges in your biopharma and pharma facilities. From upstream to downstream and through the final fill, our non-GMP facilities are resource hubs where you can explore, learn, and collaborate.
Emprove® Filters and Single-Use Components
Answering industry-wide demand for increased transparency, our Emprove® Filter and Single-use Components portfolio helps biopharmaceutical manufacturers advance their product development with confidence.

Related Webinars

Best Practices for Process Development Using Small-scale Millistak+<sup>®</sup> Filters
Best Practices for Process Development Using Small-scale Millistak+® Filters

How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.

Clarification of Mammalian Cell Culture Feed Streams Using a Cationic Flocculant, pDADMAC, and Clarisolve<sup>®</sup> Depth Filters
Clarification of Mammalian Cell Culture Feed Streams Using a Cationic Flocculant, pDADMAC, and Clarisolve® Depth Filters

pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.

Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications
Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications

Join to hear case studies on effective separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing mAbs.

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