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Merck

PRKG1

protein kinase, cGMP-dependent, type I

Synonyms:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Species:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), cow PRKG1 (282004), sheep PRKG1 (101117124), sheep PRKG1 (100294616), domestic guinea pig Prkg1 (100734084), Domestic Rabbit PRKG1 (100008694), naked mole-rat Prkg1 (101708361), chicken PRKG1 (423682) ...More
UniProtKB ID:
Q13976, E2PU10, P14619, Q5JSJ6, Q6P5T7
Gene ID:
  • Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
  • Mouse(19091) protein kinase, cGMP-dependent, type I
  • Rat(54286) protein kinase, cGMP-dependent, type 1
  • cow(282004) protein kinase, cGMP-dependent, type I
  • sheep(101117124) protein kinase, cGMP-dependent, type I
  • sheep(100294616) protein kinase, cGMP-dependent, type I
  • domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
  • Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
  • naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
  • chicken(423682) protein kinase, cGMP-dependent, type I
  • dog(609616) protein kinase, cGMP-dependent, type I
  • Horse(100071872) protein kinase, cGMP-dependent, type I
  • domestic cat(101097420) protein kinase, cGMP-dependent, type I

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ELISA

Product Number
Description
Species
CG201
cGMP Enzyme Immunoassay Kit, sufficient for 96 assays,
Species
human
CG200
cGMP Enzyme Immunoassay Kit, Direct, sufficient for 96 assays,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1306183
ANTI-CGKI (CGKI BETA)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
WH0005592M3
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 2B3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
SAB1404246
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 5E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
09-101
Anti-cGMP (cyclic GMP) Antibody, serum, Upstate®,
Species Reactivity
all
Application
ELISA
immunohistochemistry
radioimmunoassay
SAB1411090
Anti-PRKG1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Proteins

Product Number
Description
Species
SRP0371
PKG1alpha active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Species
human
14-650-M
PKG1β Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1β, for use in Kinase Assays.,
Species
human
R8282
PRKG1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
P3738
Protein Kinase G Iβ human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution,
Species
human
14-688-M
PKG1α Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
EHU145811
MISSION® esiRNA, targeting human PRKG1,
Species
human
EMU035791
MISSION® esiRNA, targeting mouse Prkg1,
Species
mouse