ASXL1
additional sex combs like 1 (Drosophila)
Synonyms:
BOPS, MDS
Species:
Human ASXL1 (171023), Mouse Asxl1 (228790), Rat Asxl1 (311553), Zebrafish asxl1 (403066), domestic cat ASXL1 (101100957), Horse ASXL1 (100068681), cow ASXL1 (522091), dog ASXL1 (100688017), chicken ASXL1 (428158), sheep ASXL1 (101113692) ...More
UniProtKB ID:
Gene ID:
- Human(171023) Summary: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- Mouse(228790) additional sex combs like 1
- Rat(311553) additional sex combs like 1
- Zebrafish(403066) additional sex combs like 1 (Drosophila)
- domestic cat(101100957) additional sex combs like 1 (Drosophila)
- Horse(100068681) additional sex combs like 1 (Drosophila)
- cow(522091) additional sex combs like 1 (Drosophila)
- dog(100688017) additional sex combs like 1 (Drosophila)
- chicken(428158) additional sex combs like 1 (Drosophila)
- sheep(101113692) additional sex combs like 1 (Drosophila)
- domestic guinea pig(100732603) additional sex combs like 1 (Drosophila)
- naked mole-rat(101705975) additional sex combs like 1 (Drosophila)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ASXL1 Antibody, clone 12F9, ,
Species Reactivity
human
Application
immunocytochemistry
western blot
western blot
Monoclonal Anti-ASXL1 antibody produced in mouse, clone 6E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot