C3042

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

• Synonym(s): CRF, CRH
• Empirical Formula (Hill Notation): C₂₀₈H₃₄₄N₆₀O₆₃S₂
• CAS Number: 86784-80-7
• Molecular Weight: 4757.45
• MDL number: MFCD00213806
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human; rat
• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: powder
• mol wt: 4757.45
• storage condition: (Keep container tightly closed in a dry and well-ventilated place)
• technique(s): activity assay: suitable
• solubility: water: 1.00-1.04 mg/mL, colorless
• UniProt accession no.: P06850
• storage temp.: −20°C
• InChI key: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• Gene Information: human ... CRH(1392)

Description

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves