A7075
Adrenocorticotropic Hormone rat
≥95% (HPLC)
Synonym(s):
Adrenocorticotropic hormone fragment 1-39, Corticotropin A
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About This Item
Empirical Formula (Hill Notation):
C210H315N57O57S
CAS Number:
Molecular Weight:
4582.16
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32
form:
powder
Assay:
≥95% (HPLC)
Recommended Products
sterility
non-sterile
Quality Level
Assay
≥95% (HPLC)
form
powder
solubility
1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
rat ... Pomc(24664)
Amino Acid Sequence
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe
Biochem/physiol Actions
Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
Other Notes
Lyophilized from 0.1% TFA in H2O
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Hasan Arrat et al.
PloS one, 10(5), e0125638-e0125638 (2015-05-09)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1
Carla Schulz et al.
American journal of physiology. Endocrinology and metabolism, 298(2), E237-E244 (2009-11-19)
ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH) are both consecutively processed from proopiomelanocortin (POMC), which is synthesized in hypothalamic arcuate neurons innervating the paraventricular nuclei (PVN). POMC secretion/synthesis is regulated by energy availability. ACTH and alpha-MSH bind with equal affinity to melanocortin-4
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