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Sigma-Aldrich

KitAlysis™ High-Throughput Medium (5, 6, 7) Ring Closing Metathesis Reaction Screening Kit - Pack of 2

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About This Item

UNSPSC Code:
12161600
NACRES:
NA.22

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

storage temp.

2-8°C

Categorías relacionadas

Application

Screening kit for ring closing metathesis. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.

Step-by-Step Guide for Ring Closing Metathesis/Cross Metathesis Reaction Screening Kit

Downloadable experimental excel file

Each kit contains 2 customizable screening sets that include the following components:
  • 6x4 pre-weighed catalysts in glass microvials loaded with stir bars and topped with cap mat.
  • 2 (2 mL) ampules each of of ClPh, PhMe, i-PrOAc, Me-THF, and TFA.
  • 1 KitAlysis 24-well reaction block replacement film.
  • 4 empty substrate stock solution reaction vials with stir bars.
  • 1 internal standard.
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reaction in parallel.
  • 20 μmol reactions with 1 μmol catalyst (5 mol%), 0.2 M concentration, and optional TFA additive.
  • Customizable and downloadable excel template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Solo componentes del kit

Referencia del producto
Descripción
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • 569747Grubbs Catalyst® M204, Umicore 3 µmolSDS
  • 569755Hoveyda-Grubbs Catalyst® M720, Umicore, 97% 3 µmolSDS
  • 579726Grubbs Catalyst® M102, Umicore, 97% 3 µmolSDS
  • 682365Grubbs Catalyst® M207, Umicore 3 µmolSDS
  • 682373Hoveyda-Grubbs Catalyst® M721, Umicore 3 µmolSDS
  • 729345Hoveyda-Grubbs Catalyst® M722, Umicore 3 µmolSDS
  • 900519Isopropyl acetate, anhydrous, ZerO2®, ≥99.6% 8 mLSDS
  • 9005202-Methyltetrahydrofuran, anhydrous, contains 250 ppm BHT as stabilizer, ZerO2®, ≥99.0% 8 mLSDS
  • 900521Chlorobenzene, anhydrous, ZerO2®, 99.8% 8 mLSDS
  • 900522Toluene, anhydrous, ZerO2®, 99.8% 8 mLSDS
  • Z118850Spinbar® magnetic stirring fleas, red, L 10 mm, diam. 3 mm 1 EASDS
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Optional

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical

Artículos

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Protocolos

Catalyst Screening followed by TLC-MS for Reaction Progress Analysis using KitAlysis™

Catalyst screening, KitAlysis™ High-Throughput Screening Kits, Thin layer chromatography (TLC), parallel analysis, parallel synthesisigh-Throughput Buchwald-Hartwig Amination Reaction Screening Kit, TLC-MS analysis

Contenido relacionado

Reaction Design & Optimization

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

Diseño y optimización de reacciones

El diseño y la optimización de reacciones químicas en la síntesis orgánica tiene como objetivo alterar con precisión parámetros de la reacción para conseguir resultados óptimos en la búsqueda de vías hacia moléculas específicas.

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