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KITALYSIS-CN

Sigma-Aldrich

KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Sinónimos:

Amination Screening Kit, Buchwald-Hartwig Amination

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.22

reaction suitability

reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reagent type: catalyst
core: palladium

storage temp.

room temp

Categorías relacionadas

General description

The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Solo componentes del kit

Referencia del producto
Descripción
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mLSDS
  • 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mLSDS
  • 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mLSDS
  • 747130Josiphos SL-J009-1 Pd G3 5 µmolSDS
  • 753009SPhos Pd G2 5 µmolSDS
  • 753246RuPhos Pd G2 5 µmolSDS
  • 756482P(t-Bu)3 Pd G2 5 µmolSDS
  • 761605BrettPhos Pd G3, 98% 5 µmolSDS
  • 762229tBuXPhos Pd G3, 98% 5 µmolSDS
  • 763004CPhos Pd G3, 95% 5 µmolSDS
  • 763039XantPhos Pd G3, 95% 5 µmolSDS
  • 763381XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmolSDS
  • 792357MorDalphos Pd G3 5 µmolSDS
  • 804959DavePhos-Pd-G3, 95% 5 µmolSDS
  • 804967rac-BINAP-Pd-G3, 95% 5 µmolSDS
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Optional

Referencia del producto
Descripción
Precios

Related product

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

target_organs

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

supp_hazards

EUH019

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

Si necesita más asistencia, póngase en contacto con Atención al cliente

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical

Artículos

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

KitAlysis™ High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit

Materials included in your KITALYSIS-CUCN-2PK High-Throughput Screening Kit

KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit

Materials Included in your KITALYSIS-24PD-2PK High-Throughput Screening Kit

Scale-Up Guide: Buchwald-Hartwig Amination Reaction

All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form. Once activated by base under the reaction conditions they become sensitive to air. To best enable scale-up success, the use of standard Schlenk technique is recommended.

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Protocolos

Catalyst Screening followed by TLC-MS for Reaction Progress Analysis using KitAlysis™

Catalyst screening, KitAlysis™ High-Throughput Screening Kits, Thin layer chromatography (TLC), parallel analysis, parallel synthesisigh-Throughput Buchwald-Hartwig Amination Reaction Screening Kit, TLC-MS analysis

Contenido relacionado

One Solvent (Dioxane), two bases (NaOtBu, Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Reaction Design & Optimization

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

Diseño y optimización de reacciones

El diseño y la optimización de reacciones químicas en la síntesis orgánica tiene como objetivo alterar con precisión parámetros de la reacción para conseguir resultados óptimos en la búsqueda de vías hacia moléculas específicas.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico