900863

2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

≥95%

• Sinónimos: 3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol, Hydroxyl diazirine alkyne, Probe building block
• Fórmula empírica (notación de Hill): C₇H₁₀N₂O
• Número de CAS: 1450754-41-2
• Peso molecular: 138.17
• MDL number: MFCD29918290
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥95%
• form: liquid
• density: 1.08 g/mL
• storage temp.: −20°C
• SMILES string: OCCC1(N=N1)CCC#C

Descripción

Application

2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks

Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases

In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors

Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable