145904

Quinine

90%

• Sinónimos: 6′-Methoxycinchonidine
• Fórmula empírica (notación de Hill): C₂₀H₂₄N₂O₂
• Número de CAS: 130-95-0
• Peso molecular: 324.42
• Beilstein/REAXYS Number: 91867
• EC Number: 205-003-2
• MDL number: MFCD00198096
• UNSPSC Code: 12352104
• PubChem Substance ID: 24848751
• NACRES: NA.22

Propiedades

• Quality Level: 200
• assay: 90%
• optical activity: [α]25/D −165°, c = 2 in ethanol
• mp: 173-175 °C (lit.)
• SMILES string: COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
• InChI key: LOUPRKONTZGTKE-WZBLMQSHSA-N
• Gene Information: human ... ABCB1(5243) , CYP2C9(1559) , CYP2D6(1565) ; rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

Descripción

General description

Quinine, a cinchona alkaloid found in the bark of the cinchona tree, is known for its anti-malarial property.

Application

Quinine has been used as a standard during the chemical evaluation of alkaloids in the hydroethanolic extracts of endophytic fungi obtained from the leaves of Costus spiralis by TLC.

Resolving agent for carboxylic acids. Catalyzes the kinetic resolution of furanones.

Biochem/physiol Actions

Potassium channel blocker

Other Notes

remainder hydroquinine

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves