Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• Fórmula empírica (notación de Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Número de CAS: 6119-47-7
• Peso molecular: 396.91
• EC Number: 205-001-1
• MDL number: MFCD00078498
• UNSPSC Code: 12352210
• PubChem Substance ID: 57654577
• NACRES: NA.77

Propiedades

• product name: Quinine hydrochloride dihydrate,
• Quality Level: 200
• solubility: H₂O: 0.25/5 g/mL, clear, colorless
• antibiotic activity spectrum: parasites
• mode of action: enzyme | inhibits
• SMILES string: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
• InChI key: SGVZDMWHXVXUBY-HZQSTTLBSA-N

Descripción

General description

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

Application

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

Biochem/physiol Actions

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.

Potassium channel blocker

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves