MilliporeSigma

Ethylene glycol poisoning.

Forensic science international (2005-10-18)
Peter Mygind Leth, Markil Gregersen
ABSTRACT

Ethylene glycol (EG) can be found in many agents, such as antifreeze. Ingestion of EG may cause serious poisoning. Adults are typically exposed when EG is ingested as a cheap substitute for ethanol or in suicide-attempts. Children may be exposed by accidental ingestion caused by decantation of EG to unlabeled bottles. EG has in itself a low toxicity, but is in vivo broken down to four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid. The metabolites are cell toxins that cause central nervous system depression, and cardio-pulmonary and renal failure. Glycolic acid causes severe acidosis, and oxalate is precipitated as calcium oxalate in the kidneys and other tissues. We present five case reports of fatal EG-poisoning, and review the literature concerning clinical presentation and diagnosis, pathological findings, treatment and prevention.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethylene glycol, ReagentPlus®, ≥99%
Sigma-Aldrich
Ethylene glycol, spectrophotometric grade, ≥99%
Supelco
Ethylene glycol, analytical standard
Sigma-Aldrich
Ethylene glycol, BioUltra, ≥99.5% (GC)
Sigma-Aldrich
Ethylene glycol, anhydrous, 99.8%
Supelco
Ethylene glycol, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Ethylene glycol solution, NMR reference standard, 80% in DMSO-d6 (99.9 atom % D), NMR tube size 3 mm × 8 in.
Supelco
Ethylene glycol solution, NMR reference standard, 80% in DMSO-d6 (99.9 atom % D), NMR tube size 5 mm × 8 in.
USP
Ethylene glycol, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Ethylene glycol 5 M solution