MilliporeSigma
  • Home
  • Search Results
  • Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii.

Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii.

Journal of medicinal chemistry (2013-04-26)
Timothy A Wencewicz, Marvin J Miller
ABSTRACT

Chemical syntheses and biological evaluation of biscatecholate-monohydroxamate mixed ligand sideromycins utilizing the carbacephalosporin β-lactam antibiotic loracarbef and the fluoroquinolone antibiotic ciprofloxacin are described. The mixed ligand β-lactam sideromycin (1b) had remarkably selective and extremely potent antibacterial activity against the Gram-negative pathogen Acinetobacter baumannii ATCC 17961 (MIC = 0.0078 μM). The antibacterial activity of the β-lactam sideromycin was inversely related to the iron(III) concentration in the testing media and was antagonized by the presence of the competing parent siderophore. These data suggested that active transport of the mixed ligand β-lactam sideromycin across the outer cell membrane of A. baumannii via siderophore-uptake pathways was responsible for the selective and potent antibacterial activity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Select agar
Millipore
Agar, for chromogenic media
Millipore
Agar, powder, suitable for microbiology
Millipore
Agar, suitable for microbiology
Sigma-Aldrich
Agar, microbiology tested, suitable for plant cell culture, suitable for cell culture, powder
Sigma-Aldrich
Agar, Type M, suitable for plant cell culture
Sigma-Aldrich
Agar, suitable for plant cell culture, powder
Sigma-Aldrich
Agar, ash 2.0-4.5%
Sigma-Aldrich
Agar, Bacteriological, microbiology tested, suitable for plant cell culture, granular
Sigma-Aldrich
Noble agar
Sigma-Aldrich
Agar, Type A, ash 5-6%
Millipore
Agar, suitable for microbiology
Sigma-Aldrich
Agar, High gel strength, suitable for plant cell culture
Sigma-Aldrich
Agar, Type E, suitable for plant cell culture
Sigma-Aldrich
Agar, suitable for plant cell culture
Sigma-Aldrich
Agar, Type A, suitable for plant cell culture
Millipore
Agar, high purity, low ionic content, low gel strenght
Millipore
Agar, for membrane filtration, low gel strengh
Sigma-Aldrich
Bacteriological agar, for molecular biology