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Saponins and polyphenols from Fadogia ancylantha (makoni tea).

Journal of natural products (2010-01-12)
Teresa Mencherini, Patrizia Picerno, Pasquale Del Gaudio, Michela Festa, Anna Capasso, Rita Aquino
ABSTRACT

Three new saponins (1-3) and a known saponin, together with four known polyphenolic compounds, have been isolated from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1-3 were established by analysis of their spectroscopic data. Both an ethanol-water extract of F. ancylantha and its phenolic constituents showed significant free-radical-scavenging and antimicrobial activities. No cytotoxicity, as evaluated by analysis of hypodiploid nuclei in HUVEC cells using propidium iodide staining, was observed for either the plant crude extract or its constituents.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g
Sigma-Aldrich
(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g
Isoquercitrin, primary reference standard
Sigma-Aldrich
Quercetin 3-β-D-glucoside, ≥90% (HPLC)