Synthesis of a novel, recyclable, solid-phase acylating reagent.

Bioorganic & medicinal chemistry letters (2002-06-28)
Robert B Nicewonger, Lori Ditto, Doug Kerr, Laszlo Varady
ABSTRACT

In this paper, we describe the synthesis of N-(6-cyano-1,3-dimethyl-2,4-dioxo-5-substituted-1,3-dihydropyridino[2,3-d] pyrimidin-7-yl)imides 1. We will show the synthesis of 1 using both conventional heating and microwave techniques. In addition, the imide was attached to polystyrene and this immobilized imide was equally as effective at acylating various primary and secondary amines as its solution-phase counterpart.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Propanol, BioReagent, for molecular biology, ≥99.5%