G006116

UHPLC/MS Analysis of Heroin and Related Compounds on Titan C18

application for UHPLC

Properties

• technique(s): UHPLC: suitable
• test parameters: column: Titan C18 5 cm x 2.1 mm I.D., 1.9 μm particles (577122-U); mobile phase: [A] 5 mM ammonium acetate in 95:5, water:acetonitrile; [B] 5 mM ammonium acetate in 5:95, water:acetonitrile; gradient: 0 to 100% B in 3 min, held at 100% B for 1 min; flow rate: 0.6 mL/min; pressure: 6770 psi (467 bar); column temp.: 35 °C; detector: MS-TOF, XIC; injection: 0.5 μL; sample: 1 μg/mL in 95:5, water:methanol
• suitability: application for UHPLC
• application(s): forensics and toxicology

Description

Analysis Note

This method shows heroin and related compounds separated on a Titan C18 column and MS detection. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.

Legal Information

Analyte

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®
Procaine hydrochloride, VETRANAL^®, analytical standard
Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®
Heroin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®
Alprazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®
Papaverine hydrochloride, powder
Flunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®
Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis
Noscapine hydrochloride hydrate, analytical standard
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