V4253

[β-Mercapto-β,β-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₅₃H₇₅N₁₃O₁₁S₂
• CAS Number: 77453-01-1
• Molecular Weight: 1134.37
• MDL number: MFCD00076752
• UNSPSC Code: 51111800
• PubChem Substance ID: 329829049
• NACRES: NA.32

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 1 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC2=O)C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,44-/m0/s1
• InChI key: SDFJYGJKEXYVCG-ZZTMPEIHSA-N
• Gene Information: human ... AVPR1A(552) , AVPR2(554) , OXT(5020) , OXTR(5021) ; mouse ... AVPR1A(54140) , AVPR2(12000) ; rat ... AVPR1A(25107) , AVPR2(25108) , OXT(18429) , OXTR(18430)

Description

Amino Acid Sequence

(1-Mercaptocyclohexyl)acetyl-Tyr(O-Ethyl)-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Beta-Mercapto-beta, beta-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin is a potent V1a and V2 vasopressin receptor anatgonist, used for examining the impact of vasopressin V1receptor blockade in rats.The product was also be used for visualizing cell surface V1a receptors in rat hepatocytes by using high-affinity fluorescent linear antagonist, Rhm8 -PVA.

Biochem/physiol Actions

Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• pcodes: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves