T9924
Troponin I from human heart
lyophilized powder
Synonym(s):
Tn-I
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About This Item
Recommended Products
biological source
human heart
Quality Level
form
lyophilized powder
purified by
affinity chromatography
technique(s)
inhibition assay: suitable
solubility
water: 5 vial/mL, clear, colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... TNNI3(7137)
Application
Troponin I from human heart can be used in studies whether the actin and aldolase can protect rabbit muscle lactate dehydrogenase inhibition by ascorbate or not.
Biochem/physiol Actions
The inhibiting subunit of troponin, responsible for preventing actin-myosin binding and ATPase activity.
Troponin I interacts with tropomyosin for regulating the contraction of striated muscle in a calcium-dependent manner. Additionally, Troponin I can also inhibits actomyosin ATPase and serves as a selective and potent inhibitor of angiogenesis in vivo and in vitro and of tumor metastasis in vivo.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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M A Moses et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(6), 2645-2650 (1999-03-17)
Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an enriched source of endogenous inhibitors of angiogenesis. In the course of a study designed to identify novel
Percy J Russell et al.
Journal of enzyme inhibition and medicinal chemistry, 19(1), 91-98 (2004-06-19)
Muscle-type LDH (LDH-m4) activity is critical for efficient anaerobic glycolysis. The results here show that rabbit LDH-M4 is inhibited by concentrations of ascorbate normally found in tissues. Aldolase and muscle G-actin were found to protect and to reverse inhibitions of
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