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T9429

Sigma-Aldrich

Anti-Transforming Growth Factor-β, pan antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-TGF-β, pan

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About This Item

MDL number:
MFCD00676459
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

amphibian, human, pig

technique(s)

microarray: suitable
neutralization: suitable
western blot: suitable

UniProt accession no.

P01137

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGFB1(7040) , TGFB2(7042) , TGFB3(7043)

Specificity

The antibody will neutralize the biological activity of human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, human TGF-β3, and amphibian TGF-β5.

Immunogen

mixture of recombinant human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, and recombinant amphibian TGF-β5.

Biochem/physiol Actions

The effect of intraperitoneal injection of Anti-Transforming Growth Factor-β, pan antibody produced in rabbit in monocrotaline-induced pulmonary hypertension was studied in rat model.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Steven M Driever et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1730) (2017-08-16)
To meet the growing demand for food, substantial improvements in yields are needed. This is particularly the case for wheat, where global yield has stagnated in recent years. Increasing photosynthesis has been identified as a primary target to achieve yield
Samuel P Hoile et al.
PloS one, 9(10), e109896-e109896 (2014-10-21)
Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of
Ya-Wen Hsiao et al.
Cancer immunology, immunotherapy : CII, 57(7), 1091-1104 (2008-02-09)
Many tumors down-regulate major histocompatibility complex (MHC) antigen expression to evade host immune surveillance. However, there are very few in vivo models to study MHC antigen expression during tumor spontaneous regression. In addition, the roles of transforming growth factor betal
Aikaterini J Megalou et al.
International journal of clinical and experimental medicine, 3(4), 332-340 (2010-11-13)
The role of transforming growth factor-β in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-β receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced
Ya-Wen Hsiao et al.
Journal of immunology (Baltimore, Md. : 1950), 172(3), 1508-1514 (2004-01-22)
IL-6 is a multifunctional cytokine that regulates cell growth, differentiation, and cell survival. Many tumor cells produce TGF-beta1, which allows them to evade CTL-mediated immune responses. IL-6 antagonizes TGF-beta1 inhibition of CD3 cell activation. However, whether IL-6 restores NK activity
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