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T7205

Sigma-Aldrich

Tegafur

≥98% (HPLC), powder

Synonym(s):
5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur
Empirical Formula (Hill Notation):
C8H9FN2O3
CAS Number:
Molecular Weight:
200.17
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to off-white

mp

171-173 °C (lit.)

solubility

DMSO: >50 mg/mL

storage temp.

room temp

SMILES string

FC1=CN(C2CCCO2)C(=O)NC1=O

InChI

1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)

InChI key

WFWLQNSHRPWKFK-UHFFFAOYSA-N

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Tegafur ≥98% (HPLC), powder

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

white to beige

color

white to off-white

color

white to beige

solubility

DMSO: >50 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >15 mg/mL

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT).

Biochem/physiol Actions

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Preparation Note

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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