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T2501

Sigma-Aldrich

L-Thyroxine sodium salt pentahydrate

≥98% (HPLC), powder

Synonym(s):
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, T4, Sodium levothyroxine
Linear Formula:
HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O
CAS Number:
Molecular Weight:
888.93
Beilstein:
5721845
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

mp

207-210 (dec.) (lit.)

solubility

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1

InChI key

JMHCCAYJTTWMCX-QWPJCUCISA-M

Gene Information

mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Preparation Note

L-Thyroxine sodium salt pentahydrate dissolves in 4 N NH4OH in methanol at 50 mg/ml to yield a clear to hazy, colorless to yellow solution.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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