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Key Documents

SRP8047

Sigma-Aldrich

Omentin human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Synonym(s):

ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1

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About This Item

CAS Number:
786735-12-4
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in CHO cells

tag

FLAG® tagged

assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~38 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

ligand binding assay: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q8WWA0

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ITLN1(55600)

General description

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.

Application

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.

Biochem/physiol Actions

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michael Sigal et al.
Nature cell biology, 21(7), 812-823 (2019-06-27)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an increase in proliferation of Wnt-responsive
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
Hatzios SK
Nature Chemical Biology, 12(4), 268-274 (2016)
Dan Li et al.
Oncotarget, 6(18), 16168-16182 (2015-05-13)
Recent evidence shows the emerging roles of intelectin 1 (ITLN1), a secretory lectin, in human cancers. Our previous studies have implicated the potential roles of ITLN1 in the aggressiveness of gastric cancer. Herein, we investigated the functions, downstream targets, and
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer.
Shen XD
Cytokine, 77, 50-55 (2016)
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Yang RZ
American Journal of Physiology. Endocrinology and Metabolism, 290(6), E1253-E1261 (2006)
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