Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SRP8010

Sigma-Aldrich

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

Synonym(s):

Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
1451392-36-1
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

tag

His tagged

assay

>90% (SDS-PAGE)

form

lyophilized

mol wt

~25 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P07203

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GPX1(2876)

General description

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Biochem/physiol Actions

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Physical form

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.
Xiao BH, et al.
BioMed Research International, 2016, 3029810-3029810 (2016)
Association of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease.
Zhang CX, et al.
Journal of the Chinese Medical Association : JCMA, 79, 195-195 (2016)
Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.
Donadio JL, et al.
Nutrients, 8, E81-E81 (2016)
Manon Ros et al.
Nature cell biology, 22(11), 1371-1381 (2020-10-21)
Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service