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SRP6015

Sigma-Aldrich

Endoglin human

recombinant, expressed in Sf9 cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):
HHT1, CD105, END, ORW, ENG
CAS Number:
NACRES:
NA.32

biological source

human

recombinant

expressed in Sf9 cells

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

90.0 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ENG(2022)

General description

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. Endoglin consists of a homodimer of 180 kDa with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, Activin-A, BMP-2, and BMP-7. It has been postulated that Endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 586 amino acids and having a molecular mass of 61 kDa, but as a result of glycosylation, migrates at 90 kDa under reducing conditions in SDS-PAGE. The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques.

Physical form

Lyophilized from PBS pH 7.4.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration of ~ 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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