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Key Documents

SML3655

Sigma-Aldrich

LockdownPro

≥97% (HPLC)

Synonym(s):

Tetraethyl 4,4′-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))diphthalate

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About This Item

Empirical Formula (Hill Notation):
C39H40O10
Molecular Weight:
668.73
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

assay

≥97% (HPLC)

form

(oil or liquid)

color

colorless to yellow

storage temp.

2-8°C

SMILES string

CC(C1=CC=C(C=C1)OC2=CC(C(OCC)=O)=C(C(OCC)=O)C=C2)(C3=CC=C(OC4=CC(C(OCC)=O)=C(C(OCC)=O)C=C4)C=C3)C

Biochem/physiol Actions

LockdownPro, an esterified lockdown analog with better cell permeability, is a cell permeable, potent, and selective allosteric inhibitor of phosphatase PPM1F. LockdownPro potently inhibits tissue invasion by PPM1F-overexpressing human cancer cells. It does not inhibit PPM1F in vitro.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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